Figure 5

Hypothetical application of FCD information about cognitive/motor change to individuals. A single fMRI measurement would be obtained on an individual. The corresponding FCD map would be projected onto pre-trained classifier weights which would help position the patient by expected decline along single cognitive/motor measures or combinations of them (similar to Fig. 4c). Patients in which ongoing change is expected could receive treatment and their evolution could be compared against an expected individualized trajectory, increasing sensitivity.