Figure 4 | Scientific Reports

Figure 4

From: Sex differences in Tfh cell help to B cells contribute to sexual dimorphism in severity of rat collagen-induced arthritis

Figure 4

Sex differences in the generation of Tfh cells and Tfr cells in CIA rats. Cells were obtained from lymph nodes draining inflamed joints and nearby tissues (dLNs) recovered at the peak of the clinical severity of CIA. (a) Representative flow cytometry dot plots show Foxp3 staining of CD4+ cells and CXCR5 expression on Foxp3+ CD4+ and Foxp3- CD4+ cells from dLNs of male and female rats. The number indicates the percentage in the region. Scatter plots show the frequency of CXCR5+ cells among Foxp3- CD4+ and Foxp3+ CD4+ cells and the absolute number of Tfh and Tfr cells from dLNs of male and female rats. (b) A scatter plot shows Tfr/Tfh cell ratio in dLNs of male and female rats. Data are presented as means ± SEM. Horizontal lines within scatter plots indicate mean values. n = 8 rats per group. **p < 0.01, ***p < 0.001.

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