Table 3 The maximum difference of EARs in organs obtained from different groups after the setup error simulations for all alternative techniques in breast cancer patients, and the data was based on the full mechanistic dose-response model.

From: Secondary cancer risk after radiation therapy for breast cancer with different radiotherapy techniques

Organs

Index

W-TF

2F-IMRT

6F-IMRT

VMAT

Max Difference

P

Max Difference

P

Max Difference

P

Max Difference

P

CB

G1

3.944 ± 1.893

>0.05

78.935 ± 29.664

<0.05

83.168 ± 26.839

<0.001

73.624 ± 15.009

<0.05

G2

1.559 ± 0.489

>0.05

22.750 ± 5.990

<0.001

25.485 ± 8.184

<0.001

28.810 ± 10.254

<0.05

G3

1.253 ± 0.596

>0.05

9.858 ± 12.338

>0.05

12.089 ± 6.744

>0.05

19.067 ± 8.024

<0.05

CL

G1

0.690 ± 0.293

>0.05

3.067 ± 2.264

>0.05

6.075 ± 2.635

>0.05

15.178 ± 9.002

>0.05

G2

0.461 ± 0.204

>0.05

2.102 ± 1.894

>0.05

3.768 ± 2.328

>0.05

8.514 ± 3.038

>0.05

G3

0.343 ± 0.149

>0.05

0.893 ± 0.742

>0.05

2.341 ± 1.689

>0.05

10.267 ± 8.870

>0.05

IL

G1

13.513 ± 6.388

>0.05

351.480 ± 149.585

<0.05

290.865 ± 28.100

<0.05

290.035 ± 30.123

<0.05

G2

5.084 ± 1.758

>0.05

287.046 ± 26.887

<0.05

283.481 ± 29.098

<0.05

289.754 ± 22.273

<0.05

G3

3.281 ± 2.198

>0.05

297.112 ± 61.753

<0.05

297.658 ± 51.001

<0.05

291.812 ± 50.111

<0.05

  1. Note: EAR = excess absolute risk. CB = contralateral breast, CL = contralateral lung and IL = ipsilateral lung. W-TF = 3D-CRT with two tangential fields and wedges, 2F-IMRT = IMRT with two tangential fields, 6F-IMRT = IMRT with six fields, and VMAT = VMAT with double partial arcs. G1 = group 1, G2 = group 2, G3 = group 3.
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