Figure 8 | Scientific Reports

Figure 8

From: Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants

Figure 8

Schematic illustration of CNN3 deficiency and phosphorylation induced changes in lens epithelial cell shape in association with reorganization of actin stress fibers and increased focal adhesions and a decrease in E-cadherin-based cell-cell junctions, leading to stimulation of Yap/Taz transcriptional activity, and expression of markers of epithelial to mesenchymal transition (EMT) including accumulation of extracellular matrix. These observations collectively imply a critical role for CNN3 in maintaining the lens epithelial phenotype. Upward and downward pointing arrows indicate upregulated and downregulated responses, respectively. The red and blue stains depict organization of actin filaments and focal adhesions, respectively.

Back to article page