Figure 2 | Scientific Reports

Figure 2

From: Effects of Rikkunshito treatment on renal fibrosis/inflammation and body weight reduction in a unilateral ureteral obstruction model in mice

Figure 2

Effects of Rikkunshito treatment on renal fibrosis in sham- and UUO-operated mice. (a) Representative images of Masson’s trichrome staining in kidneys of sham- and UUO-operated mice fed a standard diet and a diet containing Rikkunshito. Original magnification: ×200. Scale bar = 100 μm. (b) Area of renal fibrosis in sham- and UUO-operated mice fed a standard diet and a diet containing Rikkunshito. (c–e) Quantitative analysis of fibrosis-related gene expression in kidney of sham- and UUO-operated mice fed a standard diet and a diet containing Rikkunshito. (c) Collagen 1α, (d) collagen 4α, and (e) TGF-β. (f) Total collagen assay for whole kidney in sham- and UUO-operated mice fed a standard diet and a diet containing Rikkunshito. Values are expressed as the mean ± SE (a–e, n = 6 in each group. f, n = 7–8 in each group). *P < 0.05, **P < 0.01 vs sham-operated group. Differences between sham and UUO mice within each diet and between CTL and RKT within each surgery were analysed by two-factor ANOVA with Bonferroni’s post-test. CTL, control standard diet; RKT, diet containing Rikkunshito; UUO, unilateral ureteral obstruction.

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