Figure 3
Validation of MR QSM by comparison with PET and gamma counter measurement. (a) MRI (magnitude and QSM) images obtained before and after local injection of 89Zr-ferumoxytol. PET/CT images are shown after injection of 89Zr-ferumoxytol. The yellow circles on the baseline images for MRI show the location of the implanted tumors. Two slices of the MRI and PET images acquired after intratumoral injection of 89Zr-ferumoxytol are shown in the next two rows. (b) QSM and magnitude images of mice with subcutaneous tumor imaged before and 24 hours after tail-vein injection with 89Zr-ferumoxytol (3 mg Fe). The yellow circle denotes QSM detection of ferumoxytol distribution in tumor lesion. PET images are shown for comparison. (c) Imaging-based estimation of intratumorally injected ferumoxytol in live subjects was validated by comparison with the gamma counter measurement of ferumoxytol in harvested tumors.
