Figure 6 | Scientific Reports

Figure 6

From: Repeated intramuscular transplantations of hUCB-MSCs improves motor function and survival in the SOD1 G93A mice through activation of AMPK

Figure 6

Activation of AMPK regulated protein synthesis and iNOS pathway in the gastrocnemius muscles of hSOD1-G93A mice. (A) Expression of AMPK increased in the gastrocnemius muscles transplanted with hUCB-MSCs. (B) The intramuscular transplantation of hUCB-MSCs rescued expression of phosphorylated AKT and P70S6K proteins and ameliorated iNOS protein expression. (C) Statistical analysis of pAMPK, AKT, pP70S6K and iNOS (n = 2~3). *P < 0.05.

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