Figure 7 | Scientific Reports

Figure 7

From: Repeated intramuscular transplantations of hUCB-MSCs improves motor function and survival in the SOD1 G93A mice through activation of AMPK

Figure 7

Representative immune-staining and quantitative analysis of neuromuscular junction in the gastrocnemius muscle of hSOD1-G93A mice. (A) Immunohistochemistry image showed NMJ denervation and rescue of NMJ after transplantation of hUCB-MSCs. (n = 3) (B) Endplate morphology was categorized into three type: pretzel, perforated and disorganized. No significant differences between vehicle and hUCB-MSCs groups. (C) Measurement of NMJ endplate area of gastrocnemius muscle of hSOD1-G93A mice. The transplantation of hUCB-MSCs ameliorated degeneration of endplate. All data represented are means ± SEM and analyzed by one way analysis. *P < 0.05, **P < 0.01, ***P < 0.001.

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