Table 1 Intra- and inter-day precision, accuracy, recovery, matrix effect and stability of rosuvastatin in rat plasma, liver tissue and cells (n = 6).
Samples | Concentration (ng/mL) | Intra-day Precision | Inter-day Precision | Stability | Matrix effect % | Recovery % | |||
|---|---|---|---|---|---|---|---|---|---|
RSD% | RE% | RSD% | RE% | Stock solution | Short-term | ||||
plasma | 10 | 10.1 | 8.19 | 7.34 | 5.21 | 95.7 | 101 | 98.2 | 99.3 |
100 | 7.75 | 3.64 | 3.07 | 0.100 | 96.4 | 98.0 | 101 | 96.7 | |
800 | 6.08 | 4.70 | 5.64 | −2.77 | 98.8 | 96.3 | 99.0 | 95.6 | |
10 | 8.41 | 4.78 | 4.28 | 2.45 | 102 | 101 | 100 | 96.8 | |
liver tissue | 100 | 5.59 | 6.90 | 3.69 | −2.76 | 98.6 | 93.6 | 99.3 | 103 |
800 | 3.89 | 6.67 | 8.25 | 7.13 | 92.9 | 96.7 | 102 | 98.2 | |
5 | 6.56 | 3.84 | 1.87 | 2.38 | 96.3 | 98.3 | 101 | 102 | |
cells | 60 | 2.31 | 5.77 | 4.68 | −0.810 | 99.1 | 96.5 | 99.5 | 99.3 |
600 | 1.96 | 3.42 | 3.57 | 4.38 | 101 | 99.8 | 101 | 100 | |
