Table 3 Impact of serum GGT level on PD risk by the presence of obesity.

From: Serum gamma-glutamyltransferase activity and Parkinson’s disease risk in men and women

aObesity

GTP

Male

p for interaction

Female

p for interaction

PD (n)

bIR

cMODEL I

dMODEL II

PD (n)

IR

MODEL I

MODEL II

Non-obese

Q1-Q3

1,462,522

56.9

1

1

0.654

1,782,904

45.9

1

1

0.005

Q4

369,356

38.5

0.72

(0.67,0.77)

0.75

(0.69,0.80)

427,301

60.7

1.19

(1.13,1.26)

1.20

(1.13,1.26)

Obese

Q1-Q3

692,321

58.0

1.14

(1.09,1.20)

1.10

(1.05,1.15)

657,391

66.6

1.24

(1.18,1.30)

1.22

(1.17,1.28)

Q4

351,088

33.2

0.78

(0.72,0.84)

0.80

(0.74,0.86)

355,522

74.1

1.31

(1.24,1.39)

1.30

(1.23,1.38)

  1. aObese subjects based on body mass index ≥25 kg/m2, bPD incidence per 1,000 person-years, cadjusted for age, dadjusted for age, BMI, income, smoking, alcohol drinking, and exercise; income categorized as the lower quartile of income and the others; smoking and alcohol drinking as yes or no; doing exercise defined as at least 20 minutes ≥1 time/week.
  2. GGT, gamma-glutamyltransferase; PD, Parkinson disease; IR, incidence rate; HR, hazard ratio; CI, confidence interval; Q1, quartile 1; Q2, quartile 2; Q3, quartile 3; Q4, quartile 4.
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