Figure 1 | Scientific Reports

Figure 1

From: Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes

Figure 1The alternative text for this image may have been generated using AI.

Immune marker score analysis in association with histological variants and molecular subtypes. (a) Unsupervised hierarchical clustering of all UC cases. Each row is a marker and each column is a patient. Top bar indicates histological variants and molecular subtypes. (b) Distribution of histological variants (CIS, NIPUC, and invasive UC) and immune high and immune low clusters (Chi-square test, p < 0.01); (c) NIPUC is significantly associated with immune low cluster (Fisher’s exact test, p < 0.01); (d) Invasive UC is significantly associated with immune high cluster (Fisher’s exact test, p < 0.01); (e) Distribution of molecular subtypes (urothelial-like, basal-squamous, nontype, genomically-unstable, mesenchymal) in immune high and immune low clusters (Chi-square test, p < 0.05); (f) Genomically-unstable subtype is significantly associated with immune high cluster (Fisher’s exact test, p < 0.01).

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