Figure 5 | Scientific Reports

Figure 5

From: Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective

Figure 5

Gene expression of other pioglitazone targets in 3D cysts and in mouse kidneys. (a) Raw Ct-values for the expression of other pioglitazone targets (Cisd1, Ndufa9, Ppara) and Hprt (internal housekeeping gene) in DMSO- and FSK-treated 3D cysts. Higher Ct-values correspond with lower gene expression. Ct-values of 35 and higher are close to the detection limit. (b) Raw Ct-values for the expression of other pioglitazone targets (Cisd1, Ndufa9, Ppara) and Hprt (internal housekeeping gene) in wildtype, untreated (i.e. cystic) iKspCre-Pkd1del kidneys and pioglitazone-treated iKspCre-Pkd1del kidneys. Higher Ct-values correspond with lower gene expression. Ct-values of 35 and higher are close to the detection limit. Each data point represents the average of three technical replicates of 1 well (a) or 1 mouse (b). Data represent meanā€‰Ā±ā€‰SD. Ct: cycle threshold, FSK: forskolin.

Back to article page