Figure 8
From: Islet-1 synergizes with Gcn5 to promote MSC differentiation into cardiomyocytes
The epigenetic modification model of MSC differentiation into cardiomyocytes induced by islet-1. Islet-1 guides Gcn5 binding to the GATA4 and Nkx2.5 promoters, and Gcn5 interacts with G9A, HP1, DNMT-1 and HDAC1. Then, the chromatin of the GATA4 and Nkx2.5 promoter region loosened because of the hyperacetylation of these regions, which is conducive to GATA4 and Nkx2.5 expression.
