Figure 5
Modulation of TNFα production by pre-exposure to bone tissue and Staphylococcus aureus. Peripheral blood mononuclear cells of healthy rabbits were left unstimulated or were stimulated with heat-killed Εscherichia coli in the absence or presence of anti-TLR4 and anti-TLR9. Before stimulation, cells were pre-treated for 24 hours with medium, bone homogenate, heat-killed Staphylococcus aureus (HKSA) or their combination. Statistically significant comparisons are shown: ap: 0.010 versus medium; bp: 0.005 versus medium.
