Figure 3

Subnetwork of the derived GGM with emphasize on cortisol as well as piperine and related compounds (e.g. X – 11593 putatively O-methylascorbate). On each node the results from linear regression analyses for visceral fat were mapped for the whole population (black), only women (light grey) or men (dark grey) as portion of the associations strength given as –log10(FDR-value). Significant results in at least one population, false discovery rate (FDR) below 5%, were highlighted by colors. Node sizes were chosen as maximum association strength. The prefix P denotes plasma metabolites whereas U indicates urine metabolites. Edges represent significant partial correlations (par. cor.) between metabolites. Type and color represent metabolite and fluid dependencies. Regression models were adjusted for age, (sex), smoking behavior, alcohol consumption, LDL-cholesterol, systolic blood pressure, and estimated glomerular filtration rate.