Table 2 Genotypic and allelic frequencies in ARHGAP15 and FAM155A of the combined German/Lithuanian cohort and published data from published GWAS.
From: Common variation in FAM155A is associated with diverticulitis but not diverticulosis
Gene | Amin/Amaj | MAF (%) | CT (%) | TT (%) | OR | Ptrend | OR (95% CI) | Pallelic | OR (95% CI) | Pgenotypic |
|---|---|---|---|---|---|---|---|---|---|---|
ARHGAP15 (rs4662344) | ||||||||||
Diverticulitis* | T/C | 19.5 | 32.8 | 3.1 | 1.20 | 0.16 | 1.27 (0.91–1.76) | 0.16 | 1.38 (0.67–2.84) | 0.38 |
Diverticulosis** | T/C | 19.5 | 29.7 | 4.7 | 1.30 | 0.02 | 1.28 (1.00–1.63) | 0.05 | 1.85 (0.97–3.50) | 0.06 |
Controls(no diverticulosis) | T/C | 15.9 | 26.3 | 2.7 | ||||||
Controls(no prior diverticulitis) | T/C | 18.8 | 28.8 | 4.4 | ||||||
Iceland GWAS10Diverticular disease*** | T/C | 20.9 | 1.23 (1.17–1.29) | <0.001 | ||||||
Iceland GWAS10Controls*** | T/C | 17.7 | ||||||||
MGI GWAS12****Diverticular disease | T/C | 19.1/20.0 | 0.88/0.89 | <0.001/0.07 | ||||||
MGI GWAS12****Controls | T/C | 17.3/18.0 | ||||||||
European GWAS13Diverticular disease | T/C | 17.9****** | <0.001 | |||||||
European GWAS14Controls | T/C | 17.9****** | ||||||||
FAM155A (rs67153654) | TA (%) AA (%) | |||||||||
Diverticulitis* | A/T | 14.1 | 21.9 | 3.1 | 0.68 | 0.01 | 0.66 (0.47–0.92) | 0.01 | 0.45 (0.19–1.09) | 0.07 |
Diverticulosis** | A/T | 22.8 | 35.4 | 5.1 | 1.01 | 0.90 | 1.01 (0.81–1.27) | 0.91 | 1.02 (0.61–1.72) | 0.93 |
Controls (no diverticulosis) | A/T | 22.6 | 35.2 | 5.1 | ||||||
Controls (no prior diverticulitis) | A/T | 24.3 | 37.1 | 5.8 | ||||||
Iceland GWAS10 Diverticular disease*** | A/T | 17.0 | 0.87 (0.83–0.91) | <0.001 | ||||||
Iceland GWAS10 Controls*** | A/T | 18.6 | ||||||||
MGI GWAS12*****Diverticular disease | A/T | 17.0/17.8 | 0.87/0.90 | <0.001/0.024 | ||||||
MGI GWAS12*****Controls | A/T | 19.0/19.5 | ||||||||
European GWAS13 Diverticular disease | A/T | 19.6****** | ||||||||
European GWAS13 Controls | A/T | 19.6****** | ||||||||