Table 2 Genotypic and allelic frequencies in ARHGAP15 and FAM155A of the combined German/Lithuanian cohort and published data from published GWAS.

From: Common variation in FAM155A is associated with diverticulitis but not diverticulosis

Gene

Amin/Amaj

MAF (%)

CT (%)

TT (%)

OR

Ptrend

OR (95% CI)

Pallelic

OR (95% CI)

Pgenotypic

ARHGAP15 (rs4662344)

Diverticulitis*

T/C

19.5

32.8

3.1

1.20

0.16

1.27 (0.91–1.76)

0.16

1.38 (0.67–2.84)

0.38

Diverticulosis**

T/C

19.5

29.7

4.7

1.30

0.02

1.28 (1.00–1.63)

0.05

1.85 (0.97–3.50)

0.06

Controls(no diverticulosis)

T/C

15.9

26.3

2.7

      

Controls(no prior diverticulitis)

T/C

18.8

28.8

4.4

      

Iceland GWAS10Diverticular disease***

T/C

20.9

      

1.23 (1.17–1.29)

<0.001

Iceland GWAS10Controls***

T/C

17.7

        

MGI GWAS12****Diverticular disease

T/C

19.1/20.0

      

0.88/0.89

<0.001/0.07

MGI GWAS12****Controls

T/C

17.3/18.0

        

European GWAS13Diverticular disease

T/C

17.9******

       

<0.001

European GWAS14Controls

T/C

17.9******

        

FAM155A (rs67153654)

TA (%) AA (%)

Diverticulitis*

A/T

14.1

21.9

3.1

0.68

0.01

0.66 (0.47–0.92)

0.01

0.45 (0.19–1.09)

0.07

Diverticulosis**

A/T

22.8

35.4

5.1

1.01

0.90

1.01 (0.81–1.27)

0.91

1.02 (0.61–1.72)

0.93

Controls (no diverticulosis)

A/T

22.6

35.2

5.1

      

Controls (no prior diverticulitis)

A/T

24.3

37.1

5.8

      

Iceland GWAS10 Diverticular disease***

A/T

17.0

      

0.87 (0.83–0.91)

<0.001

Iceland GWAS10 Controls***

A/T

18.6

        

MGI GWAS12*****Diverticular disease

A/T

17.0/17.8

      

0.87/0.90

<0.001/0.024

MGI GWAS12*****Controls

A/T

19.0/19.5

        

European GWAS13 Diverticular disease

A/T

19.6******

        

European GWAS13 Controls

A/T

19.6******

        
  1. Genotypic and allelic frequencies of the variants. Values are given as count and percentage. Amaj = major allele; Amin = minor allele; CI = confidence interval; MAF minor allele frequency; MGI Michigan Genomics Initiative; OR = odds ratio. P Values calculated for *Diverticulitis versus Diverticulosis with no prior diverticulitis; **Diverticulosis versus healthy controls; ***refers to combined Icelandic/Danish sample; ****Data from variant rs6734367 which is in LD (r2 = 0.82) with variant rs4662344 in caucansians31, data from UK biobank/MGI; *****Data from the variant rs11619840 which is in LD (r2 = 0.93) with variant rs67153654 in caucansians31, data from UK biobank/MGI; ******Data only combined cases/controls available.