Figure 7
From: Obeticholic acid and INT-767 modulate collagen deposition in a NASH in vitro model
Collagen turnover upon tropifexor or selonsertib treatment. (a) Extracellular quantification of the total collagen upon FFAs and FXR agonists treatment vs. FFAs (dashed line). (b) or upon FXR agonists treatment vs. CTRL (dashed line). (c) Active MMP2-9 was quantified in the supernatant of SCC treated with FFAs and FXR agonists after 96 and 144 hours. Activity was normalized to the total proteins in the cell lysate and reported as percentage vs. FFAs treated sample. Data is represented as mean ± SD of at least three independent biological replicates. *p < 0.05; **p < 0.01 vs. FFAs (a) or CTRL (b).
