Figure 3
From: Machine learning decodes chemical features to identify novel agonists of a moth odorant receptor
Dose-response activities (measured via SSR), structures and ED50 values of newly identified and three previously identified ligands on SlitOR25 expressed in Drosophila ab3A OSNs. SSR responses are presented ± s.e.m. Only molecules with a significant activity in the screening tests (p < 0.05, 10−2 dilution, Fig. 2) were tested in dose-response using dilutions from 10−7 to 10−2. (a) Molecules structurally related to the known ligand acetophenone: 2′-fluoroacetophenone, 4′-fluoroacetophenone, 2′,4′-difluoroacetophenone. (b) Molecules related to the ligand benzaldehyde: 2-fluorobenzaldehyde, 3-fluorobenzaldehyde, 2,6-difluorobenzaldehyde, p-tolualdehyde. (c) Molecule related to the ligand benzyl alcohol: 2-fluorobenzyl alcohol.
