Table 3 The significant different metabolites between the HMH and PQ group.
No. | Metabolites | VIP | ROC | P value | Trend | Metabolic pathways |
|---|---|---|---|---|---|---|
1 | N-acetyl-L-aspartic acid | 1.77 | 0.88 | 0.0498 | ↑ | Alanine, aspartate and glutamate metabolism |
2 | L-Glutamic acid | 1.00 | 0.86 | 0.0075 | ↑ | Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Histidine metabolism |
3 | L-Aspartic acid | 1.06 | 0.87 | 0.0047 | ↑ | Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Histidine metabolism |
4 | mesaconic acid | 1.62 | 0.83 | 0.0113 | ↑ | Pyrimidine metabolism;C5-Branched dibasic acid metabolism |
5 | Adenosine 5′-monophosphate | 2.01 | 0.77 | 0.0267 | ↑ | Regulation of lipolysis in adipocytes;Pyrimidine metabolism |
6 | Methylmalonic acid | 1.03 | 0.94 | 0.0014 | ↑ | Pyrimidine metabolism;Valine, leucine and isoleucine degradation |
7 | Cytidine | 1.54 | 0.83 | 0.0368 | ↑ | Pyrimidine metabolism |
8 | phosphonoacetic acid | 1.25 | 0.86 | 0.0115 | ↑ | Microbial metabolism in diverse environments;Phosphonate and phosphinate metabolism |
9 | Hypotaurine | 2.52 | 0.81 | 0.0214 | ↑ | Taurine and hypotaurine metabolism |
10 | L-Glutathione (reduced) | 2.87 | 0.88 | 0.0025 | ↑ | glutathione metabolism |
11 | Cysteinylglycine | 3.13 | 0.91 | 0.0008 | ↑ | glutathione metabolism |
12 | Succinyl proline | 1.22 | 0.82 | 0.016 | ↓ | proline metabolism |
13 | Corticosterone | 1.25 | 0.8 | 0.0241 | ↓ | Regulation of lipolysis in adipocytes;Aldosterone synthesis and secretion |
14 | Prostaglandin G2 | 1.5 | 0.89 | 0.0033 | ↓ | Platelet activation |
15 | 4-Pyridoxic acid | 1.91 | 0.8 | 0.0361 | ↓ | Vitamin B6 metabolism |
16 | citric acid | 1.3 | 0.8 | 0.0222 | ↓ | TCA cycle; Alanine, aspartate and glutamate metabolism |
17 | Xanthine | 1.68 | 0.88 | 0.0062 | ↓ | Biosynthesis of alkaloids derived from histidine and purine;purine metabolism |
