Figure 4
Model of TF sliding on chromatin and predicted standard deviation of dissociation rate clusters. (a) State diagram of a TF (red box) sliding on and dissociating from DNA. Each binding position is associated with an individual binding energy. The kinetic parameters are specified in Methods. (b) Standard deviation of dissociation rates as a function of sliding length. For each sliding length, dissociation rates were obtained from 500 simulations of the sliding model depicted in (a), where the sliding length of each segment has been kept constant but the base-pair content of each segment was varied for every simulation (for details see Methods).
