Table 2 Clinical, laboratory, and exercise parameters of study participants based on ECV.

From: Left atrial dysfunction in sickle cell anemia is associated with diffuse myocardial fibrosis, increased right ventricular pressure and reduced exercise capacity

Characteristic

ECV ≤0.44 (n = 12)

ECV >0.44 (n = 12)

p Value

Age (yr)

23.0 ± 11.8

23.1 ± 9.2

0.98

Body surface area (m2)

1.68 ± 0.33

1.61 ± 0.42

0.64

Hemoglobin (g/dL)

10.3 ± 1.5

9.4 ± 1.3

0.14

Plasma free hemoglobin (mg/dL)

99 ± 137

24 ± 28

0.21

Hemoglobin F (%)

17 ± 13

19 ± 13

0.73

Heart rate at exercise cessation (BPM)

174 ± 18

162 ± 16

0.15

Peak work rate (Watt)

369 ± 332

141 ± 108

0.04

Respiratory exchange rate

1.4 ± 0.1

1.3 ± 0.2

0.17

VO2 at maximum exercise (mL/kg/min)

22 ± 2

20 ± 2

0.47

% predicted VO2 at maximum exercise

57 ± 13

54 ± 10

0.39

VE/VCO2 slope at maximum exercise

30 ± 7

32 ± 8

0.68

Moderate-to-severe exercise impairment, n (%)

8/12 (67)

4/6 (67)

0.98

VE/VO2 at maximum exercise

42 ± 11

40 ± 6

0.65

NT-Pro BNP (pg/mL)

31 (19–72)

149 (38–169)

0.008

FEV1 (%)

82 ± 12

82 ± 18

0.98

FVC (%)

87 ± 13

89 ± 14

0.76

FEV1/FVC (%)

93 ± 11

92 ± 7

0.10

  1. ECV: extracellular volume, FEV1: forced expiratory volume in the first second, FVC: forced vital capacity, RLD: Restrictive lung disease, VO2: oxygen consumption, VCO2: carbon dioxide production, Yr: Year.
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