Table 3 Echocardiographic and cardiac MRI parameters of study participants based on ECV.

From: Left atrial dysfunction in sickle cell anemia is associated with diffuse myocardial fibrosis, increased right ventricular pressure and reduced exercise capacity

Characteristic

ECV ≤ 0.44 (n = 12)

ECV > 0.44 (n = 12)

p Value

Echocardiographic Measures

TRV, m/s

2.5 ± 0.3

2.5 ± 0.7

0.96

E/A ratio

2.0 ± 0.60.6

1.8 ± 0.6

0.30

Lateral e′ (cm/s)

14 ± 4

15 ± 4

0.33

Lateral E/e′ ratio

7 ± 2

8 ± 3

0.21

Septal e′(cm/s)

10 ± 2

11 ± 1

0.21

Septal E/e′ ratio

9 ± 2

9 ± 2

0.85

Lateral a’ (cm/s)

8 ± 2

7 ± 2

0.64

Septal a’ (cm/s)

8 ± 2

7 ± 2

0.69

Heart rate

76 ± 12

77 ± 13

0.82

Systolic blood pressure

126 ± 12

121 ± 9

0.33

Distolic blood pressure

65 ± 9

60 ± 8

0.19

Atrial end diastolic volume(mL/m2)

30 ± 10

29 ± 14

0.85

Atrial end systolic volume (mL/m2)

70 ± 18

62 ± 32

0.40

Atrial ejection fraction (%)

60 ± 7

49 ± 11

0.02

Atrial global longitudinal strain (%)

32 ± 8

26 ± 9

0.08

Atrial fractional area change (%)

44 ± 7

37 ± 9

0.07

Atrial reservoir strain (%)

40 ± 7

33 ± 10

0.04

Atrial conduit strain

31 ± 7

26 ± 8

0.17

Atrial pump strain

9 ± 4

7 ± 2

0.17

Atrial positive strain rate

1.3 ± 0.2

1.0 ± 0.3

0.01

Atrial early negative strain rate

−1.4 ± 0.5

−1.2 ± 0.4

0.45

Atrial late negative strain rate

−0.8 ± 0.2

−0.7 ± 0.4

0.56

Left atrial stiffness

0.18 ± 0.05

0.26 ± 0.10

0.03

Cardiac MRI Measures

LAVi, mL/m2

50 ± 13

55 ± 12

0.39

LVEDVi, mL/m2

101 ± 21

119 ± 22

0.06

LVESVi, mL/m2

38 ± 10

48 ± 15

0.08

LVSVi, mL/m2

61 ± 13

71 ± 12

0.08

LVEF, %

62 ± 4

60 ± 6

0.31

RV cardiac index, L/min per m2

62 ± 15

67 ± 20

0.50

RVEDVi, mL/m2

105 ± 23

119 ± 28

0.18

RVEDVi, mL/m2

105 ± 23

119 ± 28

0.18

RVESVi, mL/m2

43 ± 4

52 ± 5

0.15

RVSVi, mL/m2

62 ± 12

68 ± 13

0.31

RVEF, %

59 ± 5

57 ± 5

0.25

LV cardiac index, L/min per m2

4.6 ± 1.0

5.3 ± 1.4

0.18

RV cardiac index, L/min per m2

4.6 ± 1.0

4.7 ± 2.0

0.84