Figure 3
From: The upper cervical spinal cord in ALS assessed by cross-sectional and longitudinal 3T MRI
Relationship between baseline mean cervical spinal cord cross-sectional area (CSA) and various variables in ALS. CSA relates to baseline (a) age, (b) total revised ALS functional rating scale (ALSFRS-R), (c) disease duration, (d) cortical thickness of left precentral gyrus, (e) total adjusted gray matter (GM) volume. Some patients labelled PLS did not fulfill the demand of a period of at least 4 years with UMN signs only at the time of 3T MRI, but would go on to be diagnosed with PLS after the study’s conclusion. FS, Freesurfer; FSL, FMRIB Software Library; LMND, lower motor neuron dominant ALS; UMND, upper motor neuron dominant ALS; PLS, primary lateral sclerosis. P-values ≤ 0.05 were deemed statistically significant.
