Table 2 Relative risks of factors influencing neurodevelopmental outcome.

From: Surgical necrotizing enterocolitis but not spontaneous intestinal perforation is associated with adverse neurological outcome at school age

Independent variable

Intelligence quotient <85

Cerebral palsy

RR (95% CI)

p-value

p-value§

RR (95% CI)

p-value

p-value§

Birth weight

1.0 (1.0–1.0)

0.871

1.000

1.0 (1.0–1.0)

0.421

1.000

Gestational age (per week)

0.9 (0.8–1.0)

0.013

0.224

0.8 (0.7–1.1)

0.066

1.000

Female gender

0.7 (0.8–0.9)

0.016

0.256

0.7 (0.4–1.1)

0.120

1.000

ICH ≥ grade 3 and PVL

2.7 (2.0–3.6)

<0.001

<0.001

5.2 (4.4–6.0)

<0.001

<0.001

Neurosurgery

2.8 (1.4–4.5)

<0.001

0.005

2.4 (1.2–3.8)

<0.001

0.003

European origin

1.7 (1.5–1.9)

<0.001

<0.001

1.3 (0.9–1.7)

0.226

1.000

Administration of surfactant

1.0 (0.7–1.3)

0.861

1.000

1.2 (0.6–2.0)

0.602

1.000

BPD

1.9 (1.3–2.7)

<0.001

0.015

1.6 (1.0–2.4)

0.020

0.411

SGA

1.9 (1.3–2.7)

0.001

0.019

1.3 (0.6–2.6)

0.431

1.000

Maternal education level

0.5 (0.3–0.6)

<0.001

<0.001

1.1 (0.7–1.5)

0.808

1.000

NEC

3.0 (1.8–4.2)

<0.001

<0.001

1.3 (0.5–3.1)

0.367

1.000

SIP

1.0 (0.4–2.1)

0.985

1.000

1.2 (0.4–2.7)

0.909

1.000

  1. Relative risk (RR) and corresponding 95% confidence intervals of postnatal factors influencing neurodevelopmental outcome deriving from logistic regression (controlled for birth weight, gestational age (per weeks), female gender, ICH ≥ grade 3 and PVL, neurosurgery, European origin, administration of surfactant, BPD, SGA, and maternal education level (coded as maternal school attendance > 10 years)); §Bonferroni-Holm correction (corrected for each model), significant findings (p < 0.05) are given in bold.
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