Table 2 Univariate and multivariate analysis of OS in 43 patients treated up-front with VTD.

From: High-density neutrophils in MGUS and multiple myeloma are dysfunctional and immune-suppressive due to increased STAT3 downstream signaling

n

  

Univariate analysis

Multivariate analysis

OS @ 36 months

p-value

HR (95% CI)

p-value

Gender

male

30

63.3

0.12

  
 

female

13

43.3

ISS

I-II

24

75.0

0.01

1.5 (0.5–4.3)

0.40

 

III

19

31.6

FISH risk

standard

38

60.0

0.74

  
 

high

5

52.2

Hb < 10 g/dL

no

11

81.8

0.05

  
 

yes

32

46.2

LDH > 2 UPN

no

28

89.7

0.0004

1.7 (0.7–3.9)

0.21

 

yes

15

39.5

Histotype

IgG

36

75.0

0.82

  
 

IgA

4

52.5

ClCr

<30 ml/min

8

53.9

0.78

  
 

>30 ml/min

35

62.5

CD64 MFI on CD15 + cells

normal

28

71.1

0.004

2.3 (0.9–5.8)

0.07

 

high

15

26.7

CD16 MFI on CD15 + cells

normal

24

66.7

0.46

  
 

low

17

41.2

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