Figure 5
From: Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans
HLA \({f}_{adj}^{\ast }\) scores. The red crosses in panels (A–C) illustrate non-overlap measured using \({f}_{adj}^{\ast }\) for (A) HLA-A and all other HLA loci in the Lacandon dataset; (B) HLA-B and all other HLA loci in the dataset and (C) HLA-DQB1 and all other HLA loci in the dataset. For each pair of loci we also generated 5000 different random combinations of the alleles found at each locus, and calculated \({f}_{adj}^{\ast }\) scores obtained from those randomized combinations. The \({f}_{adj}^{\ast }\) scores from the random combinations are shown as blue markers. These individual markers overlay one another at the scale used here, but illustrate the distribution of randomized scores. The heatmap in panel (D) indicates by how many standard deviations of the randomized \({f}_{adj}^{\ast }\) score distribution the actual \({f}_{adj}^{\ast }\) for a pair of loci in the Lacandon dataset exceeds the mean of the randomized \({f}_{adj}^{\ast }\) distribution for that pair.
