Table 6 The extension of HLA Conserved Extended Haplotypes* (CEH) to HLA−A in 218 Lacandon Native Americans.
From: Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans
HLA~A~B~C~DRB1~DQB1 haplotype | H.F. | n (N = 218) | Δ′ | p | t |
|---|---|---|---|---|---|
A*31:01~B*40:02~C*03:04~DRB1*04:11~DQB1*03:02 | 0.1311 | 57 | 0.9216 | 0.0000 | 14.8 |
A*02:06~B*35:01~C*07:02~DRB1*04:11~DQB1*03:02 | 0.0483 | 21 | 0.4003 | 0.0013 | 4.7 |
A*24:02~B*35:12~C*04:01~DRB1*04:11~DQB1*03:02 | 0.0483 | 21 | 0.6079 | 0.0000 | 6.3 |
A*68:03~B*35:01~C*07:02~DRB1*16:02~DQB1*03:01 | 0.0483 | 21 | 0.7020 | 0.0000 | 9.1 |
A*68:01~B*40:08~C*03:04~DRB1*04:07~DQB1*03:02 | 0.0460 | 20 | 0.6303 | 0.0000 | 7.7 |
A*68:01~B*39:05~C*07:02~DRB1*04:11~DQB1*03:02 | 0.0414 | 18 | 0.5608 | 0.0001 | 5.5 |
A*68:03~B*39:05~C*07:02~DRB1*04:07~DQB1*03:02 | 0.0391 | 17 | 0.6226 | 0.0000 | 7.0 |
A*24:02~B*40:02~C*15:02~DRB1*14:06~DQB1*03:01 | 0.0322 | 14 | 1.0000 | 0.0000 | 7.5 |
A*02:01~B*18:01~C*07:01~DRB1*11:04~DQB1*03:01 | 0.0253 | 11 | 0.8417 | 0.0000 | 6.6 |
A*02:01~B*35:12~C*04:01~DRB1*04:11~DQB1*03:02 | 0.0230 | 10 | 0.7386 | 0.0006 | 4.9 |
A*24:14~B*35:01~C*04:01~DRB1*04:04~DQB1*03:02 | 0.0230 | 10 | 1.0000 | 0.0000 | 6.2 |
A*02:06~B*40:02~C*03:04~DRB1*04:11~DQB1*03:02 | 0.0207 | 9 | 0.5174 | 0.0121 | 3.6 |
A*24:14~B*40:02~C*03:04~DRB1*14:02~DQB1*03:01 | 0.0207 | 9 | 0.8072 | 0.0000 | 5.8 |
A*02:06~B*35:01~C*07:02~DRB1*04:07~DQB1*03:02 | 0.0161 | 7 | −0.0933 | 0.7592 | −0.5 |
A*24:02~B*39:05~C*07:02~DRB1*04:07~DQB1*03:02 | 0.0161 | 7 | 0.4029 | 0.0066 | 3.6 |
A*68:03~B*35:01~C*07:02~DRB1*04:07~DQB1*03:02 | 0.0161 | 7 | −0.0933 | 0.7592 | −0.5 |
A*68:01~B*40:08~C*03:04~DRB1*04:03~DQB1*03:02 | 0.0115 | 5 | 0.5266 | 0.0000 | 4.2 |
A*24:02~B*35:12~C*04:01~DRB1*04:07~DQB1*03:02 | 0.0092 | 4 | −0.3709 | 0.2723 | −2.0 |
A*68:05~B*39:05~C*07:02~DRB1*04:07~DQB1*03:02 | 0.0092 | 4 | 0.5687 | 0.0097 | 3.2 |
A*02:01~B*35:43~C*01:02~DRB1*04:07~DQB1*03:02 | 0.0069 | 3 | 1.0000 | 0.0013 | 3.3 |
A*02:06~B*40:02~C*03:04~DRB1*14:02~DQB1*03:01 | 0.0069 | 3 | 0.1845 | 0.0060 | 2.7 |
A*02:06~B*52:01~C*03:03~DRB1*04:04~DQB1*03:02 | 0.0069 | 3 | 1.0000 | 0.0000 | 3.4 |
A*24:02~B*39:06~C*07:02~DRB1*04:04~DQB1*03:02 | 0.0069 | 3 | 0.4624 | 0.0000 | 3.1 |
A*68:01~B*39:01~C*07:02~DRB1*04:11~DQB1*03:02 | 0.0069 | 3 | 0.6079 | 0.1053 | 2.3 |
A*68:01~B*39:05~C*07:02~DRB1*16:02~DQB1*03:01 | 0.0069 | 3 | 0.0605 | 0.2314 | 1.7 |
A*68:03~B*35:01~C*07:02~DRB1*04:11~DQB1*03:02 | 0.0069 | 3 | −0.7566 | 0.0005 | −5.2 |
A*02:01~B*35:12~C*04:01~DRB1*08:02~DQB1*04:02 | 0.0046 | 2 | 0.1145 | 0.1084 | 1.9 |
A*02:06~B*35:01~C*04:01~DRB1*04:04~DQB1*03:02 | 0.0046 | 2 | 1.0000 | 0.0000 | 2.7 |
A*02:06~B*35:01~C*07:02~DRB1*04:03~DQB1*03:02 | 0.0046 | 2 | 0.1599 | 0.0872 | 1.9 |
A*02:06~B*35:01~C*07:02~DRB1*04:04~DQB1*03:02 | 0.0046 | 2 | −0.1581 | 0.7929 | −0.5 |
A*02:06~B*39:08~C*07:02~DRB1*04:07~DQB1*03:02 | 0.0046 | 2 | 0.5687 | 0.0682 | 2.2 |
A*02:06~B*40:02~C*15:02~DRB1*08:02~DQB1*04:02 | 0.0046 | 2 | 1.0000 | 0.0000 | 2.7 |
A*24:02~B*35:01~C*04:01~DRB1*04:04~DQB1*03:02 | 0.0046 | 2 | 0.3549 | 0.0036 | 2.4 |
A*24:02~B*35:01~C*04:01~DRB1*04:11~DQB1*03:02 | 0.0046 | 2 | 0.0589 | 0.8606 | 0.3 |
A*24:02~B*39:05~C*07:02~DRB1*08:02~DQB1*04:02 | 0.0046 | 2 | 0.1008 | 0.1406 | 1.8 |
A*24:02~B*40:02~C*03:04~DRB1*04:11~DQB1*03:02 | 0.0046 | 2 | 0.2158 | 0.5654 | 0.9 |
A*24:02~B*40:02~C*03:04~DRB1*14:02~DQB1*03:01 | 0.0046 | 2 | 0.4699 | 0.0001 | 2.6 |
A*24:02~B*40:02~C*03:05~DRB1*04:07~DQB1*03:02 | 0.0046 | 2 | 1.0000 | 0.0089 | 2.7 |
A*24:14~B*40:02~C*03:04~DRB1*04:11~DQB1*03:02 | 0.0046 | 2 | −0.4984 | 0.2071 | −2.0 |
A*33:01~B*14:02~C*08:02~DRB1*01:02~DQB1*05:01 | 0.0046 | 2 | 1.0000 | 0.0000 | 2.7 |
A*68:01~B*35:01~C*04:01~DRB1*04:07~DQB1*03:02 | 0.0046 | 2 | 1.0000 | 0.0089 | 2.7 |
A*68:01~B*39:05~C*07:02~DRB1*04:07~DQB1*03:02 | 0.0046 | 2 | −0.6477 | 0.0710 | −3.5 |
A*68:02~B*53:01~C*04:01~DRB1*13:03~DQB1*02:02 | 0.0046 | 2 | 1.0000 | 0.0000 | 2.7 |
A*68:03~B*39:01~C*07:02~DRB1*04:07~DQB1*03:02 | 0.0046 | 2 | 1.0000 | 0.0089 | 2.7 |
A*68:03~B*39:05~C*07:02~DRB1*08:02~DQB1*04:02 | 0.0046 | 2 | 0.0259 | 0.6024 | 0.8 |
A*68:03~B*39:05~C*07:02~DRB1*16:02~DQB1*03:01 | 0.0046 | 2 | 0.0214 | 0.6792 | 0.7 |
Native American MPA CEH + HLA-A frequency: | 0.1092 | ||||
European MPA CEH + HLA-A frequency: | 0.0480 | ||||
African MPA CEH + HLA-A frequency: | 0.0066 | ||||
Asian MPA CEH + HLA-A frequency: | 0.0349 | ||||
Not previously reported CEH + HLA-A frequency: | 0.7663 | ||||
