Figure 2
From: Cerebellar Ataxia Caused by Type II Unipolar Brush Cell Dysfunction in the Asic5 Knockout Mouse
Weanling Asic5 KO mice exhibit ataxic behavior. Summary graphs of mean fall speeds (A) and fall times (B) for trained wild type (black bars) and Asic5 KO (gray bars) mice as quantified using an accelerating rotarod test. Summary data from 12 different male littermate (24.9 ± 0.2 days old, 11.2 ± 0.6 g) and 15 different male Asic5 KO (24.8 ± 0.4 days old, 11.7 ± 0.4) mice where each mouse was tested once in triplicate. Balance beam test: Summary graphs comparing the mean number of slips per step taken (C), steps taken per crossing (D), and total time taken to cross (E) for trained littermate control (black bars) and Asic5 KO (gray bars) mice during a full run on an elevated horizontal balance beam. Summary data from 13 different male littermate (28.2 ± 1.2 days old, 14.3 ± 0.8 g) and 14 different male Asic5 KO (27.8 ± 1.8 days old, 14.3 ± 1.2 g) mice where each mouse was tested once in triplicate. *Significantly different using a two tailed unpaired t-test.
