Figure 4

Asic5 influences the inherent excitability of type II UBCs. (A) Representative traces of typical action potential trains in current-clamped type II UBCs in vestibulocerebellar slices from wild type (top) and Asic5 KO (bottom) mice evoked by 200 msec 40 pA supra-threshold current injections. Summary graphs of mean resting membrane potentials (B) and membrane resistances (C) in current-clamped type II UBCs from wild type (black bars, n = 32, 15–20 slices, 5 animals, mean age P19) and Asic5 KO (gray bars, n = 28, 12–15 slices, 4 animals, mean age P18) mice. No value is significantly different. Summary graphs of mean firing frequencies (D) and interspike intervals (E) for action potentials evoked by current injections in current-clamped type II UBCs in vestibulocerebellar slices from wild type (black circles, n = 32, 5 animals) and Asic5 KO (gray boxes, n = 28, 4 animals) mice. Inset in E shows an enlarged area for significantly different values for interspike intervals evoked by current injections greater than 65 pA. Significantly different at *P < 0.05 and **P < 0.01 with t-test.