Figure 1

Simulated clone phylogenies and tumor composition. (a,b) Phylogeny and frequencies of seven clones in seven tumor samples (T1-T7) derived from EV005 tree (G7 datasets)43. (c,d) Phylogeny and clone frequencies of twelve clones and eleven tumor samples (T1-T11) derived from RK26 tree (G12 datasets)43. (e,f) One of thirty phylogenies and its tumor composition from P10 datasets35. (g,h) One example of MA datasets (out of the 60) with primary (PSec. 1 and PSec. 2) and metastatic tumors (M1–M5)13. Note that tumor purities are 100% for all the samples.