Table 2 Characteristics of primary cohort patients (N = 66).
From: Pre-operative sera interleukin-6 in the diagnosis of high-grade serous ovarian cancer
Ovarian cancer n = 33 | Benign ovaries n = 12 | Normal ovaries n = 21 | p value | Post-hoc Adjusted p value | |
|---|---|---|---|---|---|
Demographic data | |||||
Age (years) | |||||
Mean ± SD | 60.1 ± 9.1 | 54.8 ± 10.6 | 51 ± 10.1 | 0.001 | ap = 0.30 |
Median | 60.0 | 55.0 | 48.0 | bp = 0.001 | |
Range | 41–83 | 38–73 | 40–84 | cp = 0.66 | |
Body Mass Index (BMI) (kg/m2) | |||||
Mean ± SD | 29.6 ± 4.8 | 31.3 ± 3.9 | 31.3 ± 6.2 | 0.42 | |
Median | 28.0 | 32.0 | 30 | ||
BMI range | 24–40 | 24–36 | 24–43 | ||
Family history of breast/ovarian/hereditary cancer mutation | |||||
Yes | 6 | 2 | 9 | 0.13 | |
No | 18 | 4 | 7 | ||
Unknown | 9 | 6 | 5 | ||
Gene mutation | |||||
Not tested | 16 | 8 | 7 | 0.18 | |
Tested | 17 | 4 | 14 | ||
BRCA 1 mutation | 12 | 2 | 10 | 0.21 | |
BRCA 2 mutation | 4 | 1 | 5 | 0.39 | |
Lynch syndrome | 1 | 0 | 2 | 0.38 | |
Medical comorbidities | |||||
(one individual may have more than one disease) | 12 | 3 | 3 | 0.47 | |
• Hypertension | 6 | 1 | 1 | 0.87 | |
• Type 2 diabetes | 4 | 2 | 0 | 0.80 | |
• Hypercholesterolemia | 3 | 1 | 0 | 0.80 | |
• Thyroid disorders (euthyroid) | 1 | 0 | 0 | 0.73 | |
• Bronchial asthma (controlled) | 5 | 0 | 0 | 0.73 | |
• Mild chronic back pain | 3 | 1 | 0 | 0.80 | |
• History of treated breast, cervical and/or endometrial cancer 5–30 years ago | 4 | 0 | 0 | 0.73 | |
Past history of anxiety and depression not on medication | |||||
Ovarian tissue histology | |||||
No pathology | 21 | ||||
High-grade papillary serous adenocarcinoma | 33 | ||||
Benign | |||||
Serous cystadenoma | 9 | ||||
Fibrothecoma | 3 | ||||
Stage of disease | |||||
Ovarian cancer | |||||
IIIA | 1 | ||||
IIIB | 2 | ||||
IIIC | 28 | ||||
IV | 2 | ||||
Laboratory parameters | |||||
Haemoglobin (Hb) (g/L) | |||||
Mean ± SD | 119.8 ± 16.2 | 121.3 ± 20.8 | 123.8 ± 15.7 | 0.74 | |
Median | 122 | 121 | 122 | ||
Range | 80–147 | 90–170 | 93–158 | ||
Platelet (x103/μL) | |||||
Mean ± SD | 327.8 ± 139.6 | 261 ± 73.0 | 267 ± 58.7 | 0.22 | |
Median | 296 | 229 | 263 | ||
Range | 101–654 | 173–413 | 172–369 | ||
White cell count (WCC) (x109/L) | |||||
Mean ± SD | 8.51 ± 2.8 | 9.31 ± 3.2 | 10.16 ± 3.3 | 0.15 | |
Median | 8.5 | 10.2 | 10.2 | ||
Range | 3.7–16.2 | 4.4–16.4 | 5–17.7 | ||
Absolute Neutrophil Count (ANC) | |||||
(x109/L) | 5.57 ± 2.7 | 5.93 ± 2.9 | 6.86 ± 3.4 | 0.27 | |
Mean ± SD | 4.5 | 5.49 | 6.28 | ||
Median | 2.1–13.3 | 2.7–13.1 | 2.3–14.1 | ||
Range | |||||
Total Lymphocytes (x109/L) | |||||
Mean ± SD | 1.90 ± 0.60 | 2.72 ± 0.89 | 2.43 ± 0.65 | 0.001 | ap = 0.005 |
Median | 1.8 | 2.58 | 2.26 | bp = 0.02 | |
Range | 1.0–3.0 | 1.7–4.5 | 1.6–4.0 | cp = 0.99 | |
