Table 2 Univariate and multivariate analyses of predictors of overall and progression-free survival in low-grade glioma patients.

From: Extent of resection and molecular pathologic subtype are potent prognostic factors of adult WHO grade II glioma

Variable

N (%)

10yr-OS

Univariate

Multivariate

10yr-PFS

Univariate

Multivariate

(%)

p

HR

95% CI

p

(%)

p

HR

95% CI

p

Age (yr)

  

0.012

    

0.881

   

<40

66 (43)

65.6

    

63.2

    

≥40

87 (57)

58.5

    

42.8

    

Molecular subtype

  

<0.001

  

<0.001

 

<0.001

  

<0.001

DA, IDH-mutant

80 (52)

59.8

 

6.68

1.56–28.52

 

45.8

 

2.45

1.05–5.69

 

ODG

45 (29)

96

 

*

  

73.6

 

*

  

DA, IDH-wild

28 (18)

36.1

 

24.66

5.58–108.98

 

32.5

 

9.09

3.6–22.94

 

Tumor size (cm)

  

0.012

  

0.043

 

0.054

  

0.044

<6

108 (71)

71.7

 

*

  

56.5

 

*

  

≥6

42 (27)

48.7

 

1.98

1.03–3.81

 

38.2

 

1.94

1.03–3.64

 

EOR

  

<0.001

  

<0.001

 

0.003

  

0.009

GTR

71 (46)

80.6

 

*

  

66.1

 

*

  

Non-GTR

82 (54)

50.9

 

3.84

1.73–8.53

 

41.3

 

2.24

1.21–4.52

 

Tumor location

  

0.004

    

0.001

   

Frontal

82 (54)

70.1

    

60.6

    

Non-frontal

71 (46)

55.2

    

40.4

    

RT

  

0.006

    

0.403

   

Yes

102 (67)

57.1

    

50.8

    

No

51 (33)

74.4

    

54

    

CTx

  

0.098

    

0.019

  

0.011

Yes

38 (25)

76.6

    

66.2

 

*

  

No

115 (75)

55.6

    

43.7

 

2.49

1.17–5.28

 
  1. Abbreviations: DA, diffuse astrocytoma; ODG, oligodendroglioma; EOR, extent of resection; GTR, gross total resection; Tx, treatment; RT, radiotherapy; CTx, chemotherapy; OS, overall survival; PFS, progression-free survival; IDH, isocitrate dehydrogenase; *Reference category.
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