Figure 1 | Scientific Reports

Figure 1

From: A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor

Figure 1

BaP1 induces production of PGE2 in FLSs. (A) Effect of different concentrations of BaP1 on PGE2 release in FLSs incubated with various concentrations of BaP1 or RPMI (control) for 3 h. (B) Time-course of BaP1-induced PGE2 release. FLS monolayers were incubated with BaP1 (12.5 µg/mL) or RPMI (control) for 30 min, 1, 3, 6, 12 and 24 h. Supernatants were collected, and PGE2 was quantified by ELISA. Results are expressed as mean ± SEM of 4 samples. *p < 0.05 relative to control; #p < 0.05 relative to BaP1 (3.125 µg/mL); &p < 0.05 relative to BaP1 (1 h) (one-way ANOVA, Bonferroni post test in A and two-way ANOVA, Bonferroni post test in B).

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