Figure 4 | Scientific Reports

Figure 4

From: A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor

Figure 4

Intracellular PLA2s contribute to BaP1-induced PGE2 release. Isolated FLSs were pretreated with AACOCF3 (5 μM) for 1 hour and stimulated by BaP1 (12.5 mg/mL) or RPMI (control) for 3 h. Supernatants were collected and PGE2 was quantified by ELISA. Results are expressed as mean ± SEM of 4 samples. *p < 0.05 relative to control. #p < 0.05 relative to BaP1 (one-way ANOVA, Bonferroni post test).

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