Table 1 Baseline characteristics.
CRT ON (N = 251) | CRT OFF (N = 44) | P value | |
|---|---|---|---|
Demographic and Medical History | |||
Age (years ± SD) | 60 ± 0.8 | 63 ± 1.8 | 0.10 |
Male (%) | 82.9 | 84.1 | 0.84 |
Race (white, %) | 71.1 | 61.4 | 0.33 |
BMI (mean ± SD) | 29.5 ± 7.9 | 28.7 ± 5.4 | 0.47 |
ICM (%) | 51.9 | 54.8 | 0.87 |
LVAD type (HM2 vs HW, %) | 84.9 | 90.9 | 0.29 |
LVAD indication (DT vs BTT, %) | 54.3 | 51.2 | 0.72 |
INTERMACS profile (mean ± SD) | 3.3 ± 1.3 | 3.9 ± 1.4 | 0.009 |
Profile 1–2 (%) | 28.1% | 14.3% | |
Profiles 3–7 (%) | 71.9% | 85.7% | 0.049 |
Indication CRT-D (primary vs secondary, %) | 55.5 | 35.1 | 0.023 |
COPD (%) | 22.3 | 20.4 | 0.78 |
CAD (%) | 61.3 | 56.8 | 0.57 |
Pulmonary HTN (%) | 45.8 | 23.3 | 0.007 |
OSA (%) | 35.5 | 38.6 | 0.68 |
PE/DVT (%) | 9.2 | 4.6 | 0.39 |
HTN (%) | 69.3 | 52.3 | 0.026 |
DM (%) | 44.6 | 43.2 | 0.86 |
HPL (%) | 69.8 | 59.1 | 0.16 |
CVA (%) | 17.6 | 15.9 | 0.78 |
CKD (%) | 45.0 | 45.5 | 0.96 |
Smoking (%) | 55.4 | 59.1 | 0.65 |
Alcohol (%) | 22.7 | 25.0 | 0.87 |
Mean follow-up on LVAD support (years ± SD) | 1.6 ± 1.2 | 1.7 ± 1.5 | 0.42 |
Arrhythmia and Device History | |||
Atrial Arrhythmias (%) | 65.1 | 62.5 | 0.75 |
AA burden (%,mean ± SD) | 42.9 ± 42.8 | 50.0 ± 42.1 | 0.38 |
Ventricular Arrhythmias (%) | 60.3 | 76.9 | 0.048 |
ICD Shocks (%) | 35.7 | 51.3 | 0.07 |
Anti Tachycardia Pacing (%) | 36.0 | 50.0 | 0.12 |
Biventricular Pacing before LVAD implant (%,mean ± SD) | 95.8 ± 6.2 | 96.5 ± 4.5 | 0.41 |
Echocardiography | |||
LVEF (%, mean ± SD) | 15.8 ± 5.8 | 16.6 ± 7.7 | 0.50 |
LVEDD (cm, mean ± SD) | 7.2 ± 1.0 | 7.3 ± 1.2 | 0.40 |
LVESD (cm, mean ± SD) | 6.5 ± 1.1 | 6.7 ± 1.2 | 0.38 |
ECG Data | |||
QRS duration (ms, mean ± SD) | 160 ± 29 | 152 ± 29 | 0.14 |
QTc duration (ms, mean ± SD) | 535 ± 58 | 555 ± 71 | 0.09 |
Pre LVAD Medications | |||
ACE inhibitor or ARB (%) | 55.3 | 59.1 | 0.49 |
Beta Blockers (%) | 82.3 | 81.8 | 0.94 |
Digoxin (%) | 40.3 | 43.2 | 0.72 |
Amiodarone (%) | 41.1 | 39.6 | 0.75 |
Other AAT (%) | 7.3 | 6.8 | 0.92 |
Aldosterone Antagonist (%) | 44.3 | 43.2 | 0.88 |
Thiazide (%) | 12.1 | 9.1 | 0.57 |
Loop Diuretic (%) | 86.3 | 95.4 | 0.09 |
Nitrates (%) | 24.2 | 40.9 | 0.021 |
Hydralazine (%) | 13.3 | 22.7 | 0.11 |
Post LVAD Medications | |||
ACE inh or ARB (%) | 52.8 | 40.5 | 0.38 |
Beta Blockers (%) | 65.1 | 66.7 | 0.84 |
Digoxin (%) | 17.5 | 4.8 | 0.037 |
Amiodarone (%) | 50.2 | 42.9 | 0.38 |
Other AAT (%) | 10.6 | 9.5 | 0.82 |
Aldosterone Antagonist (%) | 22.5 | 19.1 | 0.69 |
Thiazide (%) | 3.0 | 7.1 | 0.18 |
Loop Diuretic (%) | 66.8 | 80.9 | 0.07 |
Nitrates (%) | 14.1 | 9.5 | 0.42 |
Hydralazine (%) | 33.2 | 16.7 | 0.044 |
