Table 2 Clinical Outcomes.

From: Continued versus Suspended Cardiac Resynchronization Therapy after Left Ventricular Assist Device Implantation

 

CRT ON N = 251

CRT OFF N = 44

P value

Adjusted HR or OR [95% CI], p valuea

Mortality and Heart Transplantation

Overall mortality, n(%)

75 (29.9)

16 (36.3)

0.37

1.14 [0.54–2.22], p = 0.71

OHT, n(%)

45 (18.0)

8 (18.2)

0.98

1.03 [0.39–2.42], p = 0.95

Cardiac Mortality, n(%)

37 (14.7)

10 (22.7)

0.16

1.25 [0.54–2.65], p = 0.58

Noncardiac Mortality, n(%)

38 (15.1)

6 (13.6)

0.73

0.59 [0.16–1.62], p = 0.33

Hospitalizations

All cause hospitalizations

3.8 ± 4.4

3.8 ± 3.0

0.88

 

All cause hospitalizations, yearly

2.3 ± 2.7

5.7 ± 15.4

0.18

0.66 [0.30–1.47], p = 0.31

Hospitalizations for ICD shock

0.2 ± 0.6

0.4 ± 0.9

0.08

 

Hospitalizations for ICD shock, yearly

0.1 ± 0.5

0.5 ± 1.6

0.14

0.91 [0.82–1.02], p = 0.08

Arrhythmias

ICD shock after LVAD, %

35.8

45.4

0.23

0.89 [0.39–2.1], p = 0.80

No. of ICD shocks after LVAD

3.6 ± 18.5

3.9 ± 7.1

0.83

 

ATP after LVAD, %

46.1

51.2

0.56

1.14 [0.47–2.73], p = 0.77

No. of ATP after LVAD

12.3 ± 52.5

60.1 ± 286

0.28

 

Post-LVAD AA, %

58.3

76.7

0.023

0.45 [0.18–1.06], p = 0.31

Post-LVAD VA, %

58.1

77.3

0.018

0.65 [0.41–1.78], p = 0.41

Echocardiography post LVAD

LVEF (%, mean ± SD)

19.7 ± 12.0

16.0 ± 5.8

0.005

 

LVEF Mean Difference (%, mean ± SD)b

3.8 ± 0.9

0.75 ± 1.5

0.18

 

LVEDD (cm, mean ± SD)

6.1 ± 1.3

7.4 ± 1.4

0.63

 

LVEDD Mean Difference (cm, mean ± SD)b

−1.0 ± 0.08

−1.0 ± 0.17

0.81

 

LVESD (cm, mean ± SD)

5.6 ± 1.6

5.6 ± 1.1

0.78

 

LVESD Mean Difference (cm, mean ± SD)b

−0.3 ± 0.1

−0.4 ± 0.2

0.80

 
  1. aThe adjustments were made for differences in the two groups: pre-LVAD VA, INTERMACS profile, pulmonary hypertension, hypertension and indication for ICD. bThe mean difference is between pre-LVAD and post-LVAD values. AA = atrial arrhythmias; ATP = anti-tachycardia pacing; CRT = cardiac resynchronization therapy; HR = hazard ratio; ICD = implantable cardioverter defibrillator; LVAD = left ventricular assist device; LVEF = left ventricular ejection fraction; LVEDD = left ventricular end diastolic dimension; LVESD = left ventricular end systolic dimension; OHT = orthotopic heart transplantation; VA = ventricular arrhythmias.
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