Table 2 Patients and grades of hypocalcemia after denosumab use.

From: Denosumab for dialysis patients with osteoporosis: A cohort study

Grade* of the lowest serum calcium

Non-HD (n = 203)

HD

p-value

CKD G1,2 (n = 104)

CKDG3a (n = 44)

CKDG3b (n = 35)

CKDG4,5 (n = 20)

(n = 121)

Grade 1 (8.0  Ca < 8.5)

1(1.0%)

1(2.3%)

3(8.6%)

5 (25%)

21(17%)

0.05

Grade 2 (7.0  Ca < 8.0)

0

0

0

0

22(18%)

0.003

Grade 3–5 (Ca < 7.0)

0

0

0

1(5%)**

0

n/a

  1. HD, dialysis; n/a, not assessed.
  2. All calcium was adjusted by serum albumin.
  3. *Common Terminology Criteria for Adverse Events (CTCAE) version 4.0.
  4. **One patient who did not take calcium/magnesium/cholecalciferol combination tablet before injection.