Table 3 RNA-seq differential gene expression.

From: Chronic irradiation of human cells reduces histone levels and deregulates gene expression

Down-regulated by 6 mGy/h and 20 mGy/h

Fold-change

EGR1

Early growth response 1

0.266

PTGS2

Prostaglandin-endoperoxide synthase 2

0.394

FCGBP

Fc fragment of IgG binding protein

0.409

IL6

Interleukin 6

0.530

CENPU

Centromere protein U

0.540

CTGF

Connective tissue growth factor

0.541

CYR61

Cysteine rich angiogenic inducer 61

0.561

CCNA2

Cyclin A2

0.584

CENPE

Centromere protein E

0.602

KIF20A

Kinesin family member 20A

0.609

KIF11

Kinesin family member 11

0.617

TOP2A

Topoisomerase (DNA) II alpha

0.622

Up-regulated by 6 mGy/h and 20 mGy/h

Fold-change

PSG2

Pregnancy specific beta-1-glycoprotein 2

3.436

BTG2

BTG anti-proliferation factor 2

2.378

SPATA18

Spermatogenesis associated 18

2.303

DDIT4

DNA damage inducible transcript 4

2.141

DDB2

Damage specific DNA binding protein 2

1.829

HMOX1

Heme oxygenase 1

1.822

PAPPA

Pappalysin 1

1.792

PPP1R3C

Protein phosphatase 1 regulatory subunit 3C

1.594

  1. List of significant transcript changes (>1.5-fold change, p < 0.01) as identified by RNA-seq analyses of primary fibroblasts chronically irradiated at either 6 or 20 mGy/h for 7 days.
Back to article page