Table 4 SASP transcript changes with chronic radiation.
From: Chronic irradiation of human cells reduces histone levels and deregulates gene expression
Fold change 6 mGy/h | Fold change 20 mGy/h | SILAC (protein) or RNA-seq (gene) | Reported direction of change | Reference | |
|---|---|---|---|---|---|
IL-6 | 0.53022 | 0.4969 | RNA only | UP | 1 |
FGF2 | — | 1.74073 | RNA | Growth factors, UP | (1) |
FGF2 | 0.992 | 1.153 | SILAC | Growth factors, UP | (1) |
FGF9 | — | 1.54853 | RNA | Growth factors, UP | (1) |
IGFBP5 | 1.317 | 2.284 | SILAC | IGFBP family, UP | 1 |
MMP1 | 3.749 | 3.147 | SILAC | UP | 1 |
MMP2 | 1.970 | 1.883 | SILAC | MMP family, UP | (1), 2 |
MMP2 | — | 3.9616 | RNA | MMP family, UP | (1), 2 |
MMP3 | — | 2.00881 | RNA | UP | 1 |
MMP11 | 2.462 | 3.485 | SILAC | MMP family, UP | (1) |
MMP14 | 1.648 | 1.550 | SILAC | MMP family, UP | (1) |
TIMP1 | 1.173 | 1.337 | SILAC | DOWN | 1, 2 |
TIMP2 | 2.289 | 1.830 | SILAC | UP | 1 |
TIMP3 | 1.102 | 1.595 | SILAC | Other TIMPs altered | (1) |
SERPINE1 | 1.364 | 1.422 | SILAC | UP (PAI-1) | 1, 2, 3 |
CTSB | 1.115 | 1.399 | SILAC | UP | 1, 2 |
CTSD | — | 1.49723 | RNA | Altered | 2 |
FN1 | 1.383 | 2.531 | SILAC | UP (fibronectin) | 1,2 |
COL2A1 | — | 13.659 | SILAC | Collagens altered | 1 |
COL13A1 | 0.653 | 2.033 | SILAC | Collagens altered | 1 |
COL4A2 | 1.781 | 1.339 | SILAC | Collagens altered | 1 |
COL11A1 | 0.496 | 1.547 | SILAC | Collagens altered | 1 |
COL8A1 | 0.850 | 1.168 | SILAC | Collagens altered | 1 |
COL4A3BP | 1.358 | 1.449 | SILAC | Collagens altered | 1 |
COL6A2 | 1.120 | 1.162 | SILAC | Collagens altered | 1 |
COL6A3 | 0.979 | 1.004 | SILAC | Collagens altered | 1 |
COL3A1 | 1.217 | 1.332 | SILAC | Collagens altered | 1, 2 |
COL1A2 | 1.239 | 1.565 | SILAC | Collagens altered | 1 |
COL6A2 | — | 4.21427 | RNA | Collagens altered | 1 |
COL21A1 | — | 0.51108 | RNA | Collagens altered | 1 |
COL14A1 | — | 0.60807 | RNA | Collagens altered | 1 |
COL4A4 | — | 2.26572 | RNA | Collagens altered | 1 |
LBR | 0.760 | 0.535 | SILAC | Laminins altered | 1 |
TMPO | 0.690 | 0.461 | SILAC | Laminins altered | 1 |
LMNB1 | 0.789 | 0.590 | SILAC | Laminins altered | 1 |
TMPO | 0.786 | 0.558 | SILAC | Laminins altered | 1 |
LAMB1 | 0.916 | 0.669 | SILAC | Laminins altered | 1 |
LMNB2 | 0.908 | 0.767 | SILAC | Laminins altered | 1 |
LAMA2 | 1.063 | 0.919 | SILAC | Laminins altered | 1 |
LMNA | 1.075 | 1.040 | SILAC | Laminins altered | 1 |
LAMA5 | 1.148 | 0.846 | SILAC | Laminins altered | 1 |
LAMB2 | 0.969 | 0.957 | SILAC | Laminins altered | 1 |
LAMA4 | 0.954 | 0.954 | SILAC | Laminins altered | 1 |
LMNA | 1.063 | 1.029 | SILAC | Laminins altered | 1 |
LAMA1 | 1.654 | 1.198 | SILAC | Laminins altered | 1 |
LAMC1 | 1.087 | 1.069 | SILAC | Laminins altered | 1 |
