Figure 1 | Scientific Reports

Figure 1

From: Tracking Gold Nanorods’ Interaction with Large 3D Pancreatic-Stromal Tumor Spheroids by Multimodal Imaging: Fluorescence, Photoacoustic, and Photothermal Microscopies

Figure 1

Schematic of the whole experimentation and of the AuNRs. (A) Schematic of the experimentation: spheroid formation (day 1 to day 5) in ultra-low-attachment 96-well plate, functionalized AuNR incubation, followed by characterization of the whole sphere and a section of it. (B) Schematic of AuNR functionalization from bare to covered with HS-PEG-COOH to allow EDC/NHS reaction conjugation of the fluorescent dye NH2-TR-BDP, which can be released by acid pH-trigger at a pH of 5.5.

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