Figure 6
From: The anti-tumoral potential of the saporin-based uPAR-targeting chimera ATF-SAP
Cytotoxic activity of ATF-SAP on ex vivo bladder cancer cells. (A) After the second implantation, established tumors were minced and tumor cells analyzed for uPAR expression by flow cytometry. Results are shown as RFI (see “Materials and Methods”) (left panel). The dashed line represents the threshold arbitrarily defining positive expression (RFI = 2). (B) Explanted cells were then incubated for 72 h with ATF-SAP and cell viability was evaluated by MTT assay (right panels). Seed SAP was used as untargeted control. Results from one representative experiment are shown as mean ± SD. Three independent experiments were performed.
