Figure 5

Conservation of C. floridanus proteins. (a) Network showing the similarity of C. floridanus proteins (central node) with other organisms proteins (peripheral nodes) quantitively by color codes. Color gradients represent the number of proteins in each species that have orthologs in either C. floridanus interactome (itor, inner circle) or in the whole C. floridanus proteome (tor, outer circle). A similar color to the ant node shows close orthology relation while nodes of more distant species have different colors. A correlation between the colors of two circles is expected to show that the interactome successfully represent the orthology relationships between ant and other species. For instance, if both circles of a species show a similar color to ant, it depicts that the close orthology to ant can be also observed in the interactome. Pearson’s Chi-squared test with Yates’ continuity correction showed relationship (p-value < 2.2e-16) between the total ant proteins orthologs and interactome proteins orthologs for each corresponding organisms. (b) Conservation of ant interactome proteins in set of any analyzed organisms. Number of ant interactome proteins that are unique to ant and that are orthologous to proteins in different numbers of analyzed species is shown. (c) Differentially expressed top hubs and bottlenecks (represented by black dots) and presence/absence of their orthologs in other seven organisms. Differential expression values (log2FC) of hubs and bottlenecks in bacterial infection of C. floridanus are represented by a color gradient.