Figure 14 | Scientific Reports

Figure 14

From: Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-κB and activating Nrf2

Figure 14

Administration of the extract of roasted coffee beans and pyrocatechol significantly reduced LPS-induced serum level of CCL2, CXCL1, IL-6, and TNFα in mice. Male C57BL/6 mice were given water, 60% (v/v) coffee extract or 74.4 μM of pyrocatechol for 3 weeks and then injected intraperitoneally with PBS or LPS (200 μg/mouse) (6 mice per group). One hours after the LPS injection, blood samples from mice were collected by cardiac puncture. The amounts of CCL2, CXCL1, IL-6, and TNFα in murine serum were measured by ELISA. *, **, and ***indicate P < 0.05, P < 0.01, and P < 0.001, respectively.

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