Figure 2
From: Protein design under competing conditions for the availability of amino acids
Folding free energy profiles F/kBT of single protein (only protein \(\bar{G}\), no protein \(\Gamma \)) at reduced temperature 0.55 as a function of DRMSD from the native target structure (protein G structure, PDB ID: 1pgb). Different colours correspond to protein \(\bar{G}\) sequences obtained via the design procedure in the presence of the protein \(\Gamma \) characterised by the \(\zeta \) value specified in the key. Right hand side: configurations corresponding to the free energy minimum for each system are represented in red, compared to the native protein G (in green). \(DRMSD=2.1\,{\rm{\AA }}\) for \(\zeta =0.20\); \(DRMSD=1.9\,{\rm{\AA }}\) for \(\zeta =0.40\); \(DRMSD=1.3\,{\rm{\AA }}\) for \(\zeta =0.60\) and \(DRMSD=1.5\,{\rm{\AA }}\) \(\zeta =0.80\).
