Table 1 Demographic and Clinical Characteristics.

From: Prevalence and risk factors of having antibodies to class I and II human leukocyte antigens in older haploidentical allograft candidates

All patients

273

Median age(range), years

54(50–66)

Gender, n (%)

Male

165(60.4%)

Female

108(39.6%)

Diagnosis, n (%)

AML

124(45.4%)

ALL

47(17.2%)

MDS

66(24.2%)

CMML

10(3.7%)

Others

26(9.5%)

Number of pregnancies, n (%)

0

168(61.5%)

1

61(22.3%)

≥2

44(16.1%)

Number of transfusions, n (%)

≤12

212(77.7%)

>12

61(22.3%)

Number of RBC transfusion, n (%)

≤7

212(77.7%)

>7

61(22.3%)

Number of platelet transfusion, n (%)

≤7

226(82.8%)

>7

47(17.2%)

Course, n (%)

≤7.5

169(61.9%)

>7.5

104(38.1%)

PRA

Class I (+), n (%)

73(26.7%)

Class II (+), n (%)

38(13.9%)

Class I and II positive, n (%)

32(11.7%)

Class I or II positive, n (%)

79(28.9%)

Anti-HLA antibodies against single locus positive

79(28.9%)

Median MFI (range)

Class I (+)

2902(558–22827)

Class II (+)

4332(516–18363)

  1. Abbreviations: AML, acute myeloid leukemia; ALL, acute lymphoblastic leukemia; MDS, myelodysplastic syndrome; CMML, chronic myelomonocytic leukemia; RBC, red blood cell; PRA, panel reactive antibody; HLA, human leukocyte antigen; MFI, mean fluorescence intensity.