Table 3 Specific antibodies against HLA-A, -B, -C, -DP, -DQ, and -DR: logistic regression analysis in 273 older allogeneic stem cell transplantation candidates.

From: Prevalence and risk factors of having antibodies to class I and II human leukocyte antigens in older haploidentical allograft candidates

 

Anti-HLA-A

Anti-HLA-B

Anti-HLA-C

Anti-HLA-DP

Anti-HLA-DQ

Anti-HLA-DR

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Gender (female vs. male)

 

NS

 

NS

2.729(1.404–5.303)

0.003

 

NS

12.615(1.020–156.051)

0.048

 

NS

Number of pregnancies

0

0.402(0.174–0.25)

0.036

0.358(0.158–0.813)

0.014

   

NS

0.254(0.082–0.790)

0.018

 

NS

1

0.243(0.118–0.501)

<0.001

0.169(0.082–0.350)

<0.001

    

2.026(0.164–25.056)

0.582

  

≥2

1

NS

1

  

NS

  

1

   

Number of total transfusions (>12 vs. ≤12)

 

NS

 

NS

 

NS

 

NS

 

NS

 

NS

Number of RBC transfusion (>7 vs. ≤7)

 

NS

 

NS

   

NS

 

NS

  

Number of PLT transfusion (>7 vs. ≤7)

2.444(1.227–4.868)

0.011

2.279(1.131–4.594)

0.021

2.678(1.266–5.663)

0.010

8.259(3.357–20.318)

<0.001

6.810(2.889–16.053)

<0.001

5.398(2.426–12.011)

<0.001

  1. Abbreviations: HLA, human leukocyte antigen; OR, odds ratio; CI, confidence interval; RBC, red blood cell; PLT, platelet.