Figure 3

Skeletal muscle ablation of Pit1 and Pit2 results in a mild renal Pi leak at P10. P10 smPit1^−/−; smPit2^−/− mice were hypophosphatemic (A) and hyperphosphaturic (B) in an FGF23-independent fashion (C). Blood glucose (D) and BUN were within normal limits (E). Means ± SEM, n = 5–10, ^***p = 0.0002, ^**p = 0.002, ^*p = 0.03 vs. WT.