Figure 7
From: Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival
Metabolic Pi-signaling in myocytes. We here provide evidence for an important function of Pit1 and Pit2 to increase intracellular Pi as a substrate for mitochondrial ATP synthesis and/or as a signal to stimulate mitochondrial respiration. Pit1 and Pit2 may also serve as “transceptors” upon binding of blood Pi to activate ERK1/2 in a transport-independent fashion to stimulate myocyte proliferation and differentiation and mitochondrial respiration.
