Figure 4
From: The scaffold protein IQGAP1 is crucial for extravasation and metastasis
IQGAP1 knockout reduces extravasation of MA2 cells in vivo. (A) Representative images of parental, IQGAP1 knockout or rescued cells (ZsGreen), vasculature (CD31), and nuclei (DAPI) 20 hours after tail-vein injection. Extravasated cells (arrows) and cells still in vasculature (arrowheads) are indicated. Scale bar, 10 µm. (B) Fraction of observed cells that had extravasated. n = 5 mice per group. ns, P > 0.05; ****P ≤ 0.0001; one-way ANOVA with Tukey’s multiple comparisons test.
