Table 2 Risk of worse breast cancer-specific or distant metastasis-free survival conferred by high protein levels of HER3, EGFR, or HER3-EGFR in age- and stage-adjusted Cox models stratified by hospital.

Model	Covariate	Chemo	Breast cancer-specific survival				Distant metastasis-free survival
			p-value	HR	95% CI for HR		p-value	HR	95% CI for HR
			p-value	HR	Lower	Upper	p-value	HR	Lower	Upper
HER3	HER3	No	0.58	1.21	0.62	2.36	0.77	1.10	0.59	2.06
	Age		0.96	1.00	0.97	1.03	0.99	1.00	0.97	1.03
	Stage		<0.001				<0.001
	II vs. I		0.51	1.24	0.65	2.38	0.27	1.42	0.76	2.63
	III vs. I		<0.001	6.63	2.96	14.85	<0.001	6.09	2.67	13.92
	HER3	Yes	0.57	1.21	0.63	2.34	0.72	1.12	0.59	2.11
	Age		0.10	1.02	1.00	1.05	1.00	1.00	0.98	1.02
	Stage		0.010				0.020
	II vs. I		0.79	1.10	0.57	2.12	0.97	1.01	0.56	1.85
	III vs. I		0.014	2.58	1.21	5.49	0.022	2.36	1.13	4.93
EGFR	EGFR	No	0.75	0.91	0.51	1.63	0.86	0.95	0.54	1.68
	Age		0.98	1.00	0.97	1.03	0.98	1.00	0.97	1.03
	Stage		<0.001				<0.001
	II vs. I		0.56	1.21	0.64	2.30	0.28	1.40	0.76	2.59
	III vs. I		<0.001	6.42	2.89	14.27	<0.001	6.02	2.64	13.75
	EGFR	Yes	0.67	1.11	0.68	1.81	0.18	1.39	0.86	2.23
	Age		0.09	1.02	1.00	1.05	0.89	1.00	0.98	1.03
	Stage		0.008				0.024
	II vs. I		0.81	1.09	0.56	2.10	0.98	1.01	0.55	1.84
	III vs. I		0.013	2.59	1.22	5.51	0.027	2.30	1.10	4.81
HER3-EGFR	HER3-EGFR	No	0.85	0.94	0.51	1.74	0.78	0.92	0.51	1.65
	Age		0.98	1.00	0.97	1.03	0.98	1.00	0.97	1.03
	Stage		<0.001				<0.001
	II vs. I		0.58	1.20	0.63	2.29	0.30	1.39	0.75	2.56
	III vs. I		<0.001	6.33	2.88	13.96	<0.001	5.99	2.66	13.48
	HER3-EGFR	Yes	0.006	2.30	1.26	4.20	0.041	1.78	1.02	3.11
	Age		0.13	1.02	0.99	1.05	0.83	1.00	0.98	1.03
	Stage		0.016				0.007
	II vs. I		0.73	1.12	0.58	2.17	0.83	1.07	0.58	1.95
	III vs. I		0.018	2.49	1.17	5.31	0.009	2.61	1.28	5.32

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